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MDMA is (3,4-methylenedioxy-N-methylamphetamine) is an empathogenic drug of the phenethylamine and amphetamine classes of drugs. MDMA has become widely known as "ecstasy" (shortened to "E", "X", or "XTC"), usually referring to its street form, although this term may also include the presence of possible adulterants. The UK term "Mandy" and the US term "Molly" colloquially refer to MDMA that is relatively free of adulterants.[3]

MDMA increases a sense of intimacy and diminished anxiety with others which can induce euphoria and mild psychedelia. Many studies, particularly in the fields of psychology and cognitive therapy, have suggested MDMA has therapeutic benefits and facilitates therapy sessions in certain individuals, a practice for which it had been formally used in the past. Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder, anxiety associated with terminal cancer[4][5] and addiction.[6]

MDMA is criminalized in most countries. Some limited exceptions exist for scientific and medical research. For 2008, the UN estimated between 10 and 25 million people globally used MDMA at least once in the past year. This was broadly similar to the number of cocaine, amphetamine, and opioid users, but far fewer than the global number of cannabis users.[7] It is taken in a variety of contexts far removed from its roots in psychotherapeutic settings, and is commonly associated with dance parties (or "raves") and electronic dance music.[8]

Regulatory authorities in several locations around the world have approved scientific studies administering MDMA to humans to examine its therapeutic potential and its effects.[9]

Medical use:

MDMA has been indicated as possibly useful in psychotherapy, facilitating self-examination with reduced fear.[10][11][12] Indeed, some therapists, including Leo Zeff, Claudio Naranjo, George Greer, Joseph Downing, and Philip Wolfson, used MDMA in their practices until it was made illegal. George Greer synthesized MDMA in the lab of Alexander Shulgin and administered it to about 80 of his clients over the course of the remaining years preceding MDMA's Schedule I placement in 1985. In a published summary of the effects,[13] the authors reported patients felt improved in various mild psychiatric disorders and experienced other personal benefits, especially improved intimate communication with their significant others. In a subsequent publication on the treatment method, the authors reported one patient with severe pain from terminal cancer experienced lasting pain relief and improved quality of life.[14] In the United States, no research on MDMA was allowed at all, from 1985 until 1992, when the FDA approved Dr. Charles Grob to conduct human studies.[15]

Note: Wikipedia
Posted by administrator on Tuesday, June 17 @ 10:43:04 EDT (268 reads) (Read More... | 68344 bytes more | Score: 0)

A Blueprint for Brain Development
A Blueprint for Brain Development Caption: An image generated by whole-brain diffusion tensor tractography, one of a variety of innovative techniques used to create the 3-D gene expression atlas of the developing human brain.
Credit: Allen Institute for Brain Science and Bruce Fischl, Massachusetts General Hospital

There is mounting evidence that predisposition to autism, schizophrenia, and many other devastating brain disorders may begin in the womb when genes are turned on or off at the wrong time during early brain development. But because our current maps of the developing brain are not nearly as detailed or dynamic as we would like, it has been a major challenge to identify and understand the precise roles of these genes.

So, I’m pleased to report that NIH-funded researchers at the Allen Institute for Brain Science in Seattle have produced a comprehensive 3-D map that reveals the activity of some 20,000 genes in 300 brain regions during mid-prenatal development [1]. While this is just the first installment of what will be an atlas of gene activity covering the entire course of human brain development, this rich trove of data is already transforming the way we think about neurodevelopmental disorders.

To test the powers of the new atlas, researchers decided to use the database to explore the activity of 319 genes, previously linked to autism, during the mid-prenatal period. They discovered that many of these genes were switched on in the developing neocortex—a part of the brain that is responsible for complex behaviors and that is known to be disrupted in children with autism. Specifically, these genes were activated in newly formed excitatory neurons, which are nerve cells that send information from one part of the brain to another. The finding provides more evidence that the first seeds for autism are planted at the time when the cortex is in the midst of forming its six-layered architecture and circuitry.

Posted by administrator on Tuesday, April 08 @ 12:58:03 EDT (299 reads) (Read More... | 5926 bytes more | Score: 0)

X-37B is a Secret Spaceplane!
X-37B is a Secret Spaceplane! The Air Force’s secret space plane has been up in orbit for nearly 500 days—a space endurance record. But nearly a year and a half into the mission, the Pentagon still won’t say what the X-37B is doing up there, or when it might come back.

The U.S. Air Force boosted the robotic X-37B atop the nose of an Atlas-5 rocket in December 2012. Since then it’s orbited the Earth thousands of times, overflying such interesting places as North Korea and Iran.

READ MORE Apps to Get Your Sherlock On

Similar to the Space Shuttle in appearance, the diminutive X-37B is about a quarter the size of the old shuttles. But there are major differences. Lacking a crew, the spacecraft has no cockpit windows. The X-37B has a payload bay about the size of a pickup truck bed.

And while the original Space Shuttle could stay in orbit for up to 17 days—a limitation largely due to the needs of the crew—the first X-37B mission, OTV-1, spent 225 days in space under the guidance of Air Force space flight controllers at Schriever Air Force Base, Colorado. The second mission, OTV-2, handily doubled that number, clocking 469 days in orbit. OTV-3 is currently at 482 days and counting.

Note: The Daily Beast
Posted by administrator on Tuesday, April 08 @ 12:45:57 EDT (245 reads) (Read More... | 5895 bytes more | Score: 0)

Neuroplasticity: how the brain is capable of change
Neuroplasticity Scientists have historically believed that once a person reaches adulthood, their cognitive abilities are immutable. But beginning in the early twentieth century, that theory has been contested by evidence suggesting that the brain’s abilities are in fact malleable and plastic. According to this principle of neuroplasticity, the brain is constantly changing in response to various experiences. New behaviors, new learnings, and even environmental changes or physical injuries may all stimulate the brain to create new neural pathways or reorganize existing ones, fundamentally altering how information is processed.

Mapping changes in taxi drivers’ brains

One of the most dramatic examples of neuroplasticity at work comes from a 2000 brain scan study on London taxi drivers (Maguire et al., 2000). In order to earn a license, London taxi drivers typically spend about two years learning to navigate the city’s serpentine streets. What mark, the study’s researchers wondered, did this long, rigorous period of training leave on taxi drivers’ brains? Under the scrutiny of fMRI scans, 16 male taxi drivers were revealed to have larger hippocampuses than a control group of 50 healthy males. And the longer the time spent as a taxi driver, the larger the hippocampus tended to be. As a brain area involved in memory and navigation, the hippocampus seemed to have changed in response to the taxi drivers’ experiences.

Posted by administrator on Friday, January 10 @ 12:54:40 EST (298 reads) (Read More... | 3779 bytes more | Score: 1)

NIH announces six funding opportunities for the BRAIN Initiative
NIH announces six funding opportunities The National Institutes of Health is releasing funding opportunities to build a new arsenal of tools and technologies for unlocking the mysteries of the brain. The NIH action is in support of President Obama’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.

The six opportunities announced today were developed in response to high priority areas(PDF - 536KB) identified by the NIH Advisory Committee to the Director’s BRAIN Working Group in September 2013. Awards are expected to be announced in September 2014 and will constitute NIH’s initial investment of $40 million in the initiative.

An illustration of a brain.

“The human brain is one of the most complicated structures in the known universe,” said NIH Director Francis S. Collins, M.D., Ph.D. “We have an unprecedented opportunity to develop new technologies that will allow us to map the circuits of the brain, measure activity within those circuits, and understand how their interactions maintain health and modulate human behavior.”

The President’s BRAIN Initiative is a large-scale inter-agency federal effort that the President described as “giving scientists the tools they need to get a dynamic picture of the brain in action and better understand how we think, how we learn, and how we remember.” Three federal agencies — NIH, National Science Foundation, and Defense Advanced Research Projects Agency, or DARPA — expect to contribute a total of $110 million in the 2014 fiscal year. NIH’s $40 million contribution in fiscal 2014 is in addition to the roughly $5.5 billion slated in the NIH fiscal 2014 budget for neuroscience research. Private organizations have also signed on to bolster this bold, interdisciplinary effort.

Posted by administrator on Wednesday, December 18 @ 11:56:13 EST (262 reads) (Read More... | 2959 bytes more | Score: 0)

Humans and Machines!
The Risk of Putting Our Knowledge in the We rely on computers to fly our planes, find our cancers, design our buildings, audit our businesses. That's all well and good. But what happens when the computer fails?

O N THE EVENING OF F EBRUARY 12, 2009 , a Continental Connection commuter flight made its way through blustery weather between Newark, New Jersey, and Buffalo, New York. As is typical of commercial flights today, the pilots didn’t have all that much to do during the hour-long trip. The captain, Marvin Renslow, manned the controls briefly during takeoff, guiding the Bombardier Q400 turboprop into the air, then switched on the autopilot and let the software do the flying. He and his co-pilot, Rebecca Shaw, chatted—about their families, their careers, the personalities of air-traffic controllers—as the plane cruised uneventfully along its northwesterly route at 16,000 feet. The Q400 was well into its approach to the Buffalo airport, its landing gear down, its wing flaps out, when the pilot’s control yoke began to shudder noisily, a signal that the plane was losing lift and risked going into an aerodynamic stall. The autopilot disconnected, and the captain took over the controls. He reacted quickly, but he did precisely the wrong thing: he jerked back on the yoke, lifting the plane’s nose and reducing its airspeed, instead of pushing the yoke forward to gain velocity. Rather than preventing a stall, Renslow’s action caused one. The plane spun out of control, then plummeted. “We’re down,” the captain said, just before the Q400 slammed into a house in a Buffalo suburb.

The crash, which killed all 49 people on board as well as one person on the ground, should never have happened. A National Transportation Safety Board investigation concluded that the cause of the accident was pilot error. The captain’s response to the stall warning, the investigators reported, “should have been automatic, but his improper flight control inputs were inconsistent with his training” and instead revealed “startle and confusion.” An executive from the company that operated the flight, the regional carrier Colgan Air, admitted that the pilots seemed to lack “situational awareness” as the emergency unfolded.

The Buffalo crash was not an isolated incident. An eerily similar disaster, with far more casualties, occurred a few months later. On the night of May 31, an Air France Airbus A330 took off from Rio de Janeiro, bound for Paris. The jumbo jet ran into a storm over the Atlantic about three hours after takeoff. Its air-speed sensors, coated with ice, began giving faulty readings, causing the autopilot to disengage. Bewildered, the pilot flying the plane, Pierre-Cédric Bonin, yanked back on the stick. The plane rose and a stall warning sounded, but he continued to pull back heedlessly. As the plane climbed sharply, it lost velocity. The airspeed sensors began working again, providing the crew with accurate numbers. Yet Bonin continued to slow the plane. The jet stalled and began to fall. If he had simply let go of the control, the A330 would likely have righted itself. But he didn’t. The plane dropped 35,000 feet in three minutes before hitting the ocean. All 228 passengers and crew members died.

Note: Nicholas Carr is the author of The Shallows and the forthcoming The Glass Cage. His article “Is Google Making Us Stupid?” appeared in the July/August 2008 Atlantic.
Posted by administrator on Wednesday, October 30 @ 09:55:29 EDT (288 reads) (Read More... | 26678 bytes more | Score: 0)

From Trojan Horse to the Golden Calf—the Power of Deceit!
From  Trojan Horse to the Golden Calf Little in this world is new but the means to do it; our actions and our behaviors are but regurgitations of our heritage. Our Western world gorges on its past and glorifies in it. Our children memorize and are mesmerized by the deeds of heroic figures the likes of Achilles and Oedipus, glorified by the great chronicler Homer, deeds done with power and deceit. Our children and our adults flock even now in 2004 to witness the fall of Troy with Brad Pitt extolling the virtues of Achilles and Sean Bean acting the sly Odysseus. Our hearts and our desires throb to theirs; we faint and flutter at their heroics as we witness the carnage of their exploits and the splendor of their victories.

Our minds find the means to their ultimate success in the deception fabricated by Odysseus, the great Trojan Horse, a monstrous sculpted symbol of conceded victory offered by the Greeks to their vanquishers. Our minds marvel at the simplicity of the deception, a mixture of apparent kindness, of supplication, of forgiveness, of beauty, of hopefulness, but ultimately our minds recognize the power of the mental cruelty that creates out of such darkness the power to destroy, to massacre, to devastate, to cripple, to maim, to slaughter the lives of all who lived and loved and prayed behind the walls of Troy. We do not anticipate that Priam or Hector or the wives of Troy will be our guides through this mayhem, just those with the power, the will, the means to deceive; in that mixture rests success.

How appropriate the film appeared in 2004 as Ariel Sharon forced the world to conceptualize a 21st century power as it constructs a wall to incarcerate an indigenous people, walling them in as opposed to storming their wall to destroy them. Done we are told to defend the state of Israel, not to continue in this new civilized century the slow motion genocide of the Palestinians. How unfortunate that the Israeli military, with the fourth largest state of the art assemblage of weaponry on the planet, cannot defend itself against a people that have no military at all. How to convince the world that they are the victims not the Palestinians? To deceive or not to deceive is not the question; the question is what is the means of deception since one cannot put a sculptured horse inside the Bantustans that constitute the mythological state of Palestine.

Today, John Kerry, our new Secretary of State, flits around the mid–east by phone or jet to proffer a last stand “peace” talk initiative between Netanyahu and Abbas with the trump card held above their respective heads that the US will withdraw from its role as interlocutor leaving the two parties to solve their differences on their own, something a kin to Achilles hauling the dead Hector behind his chariot around his Father’s city to the delight of his mercenaries. Think of it: without the deception that America offered to the world, a pseudo-determined effort to control Israeli expansion further into Palestinian land and their ostensible state, Netanyahu can further corral the millions of Palestinians into tighter and tighter quarters as Settlers (read squatters) steal yet more of what’s left of Mandate Palestine. As long as Netanyahu can count on the US veto in the Security Council, he has nothing restraining his efforts to rid the land of Arabs as his Zionist predecessors so desired.

Note: William Cook

Prof. William A. Cook is Professor of English at the University of La Verne in southern California. He serves as senior editor at MWCNEWS. His commentary and analysis have been featured in several online publications. He is author of The Rape Of Palestine: Hope Destroyed, Justice Denied.
Posted by administrator on Sunday, June 09 @ 02:01:34 EDT (347 reads) (Read More... | 17000 bytes more | Score: 0)

Enhancing Effects of Caffeine on Aging Visuo-spatial
Enhancing Effects of Caffeine Visuo-spat Attention: fMRI Design and BOLD Signal

I. Introduction

History and Metabolism

Coffee is the most consumed psychoactive drug since ancient times due to its beneficial effects on arousal, attention, psychomotor function, and memory. Legendary goat keeper Kaldi in Ethiopia discovered that his goats did not sleep at night after eating coffee berries between 300- 800 AD. He brought berries to local abbott and the first coffee brew was made. Then coffee brought to Arabic world and Venice in early 17th century. It was used first as medicine and then as a social drink. In 1819 Friedrich Ferdinand Runge at the behest of von Goethe isolated caffeine from coffee beans. In famous “Faust” by Goethe the soul of Faust was sold to the devil in exchange for “jeunesse” (coffee beans). Almost 200 years ago Johann Wolfgang von Goethe already predicted that coffee can treat many diseases and slow down ageing. Herman Fisher elucidated the caffeine structure at the end of 19th century.

Note: Dr. Victor Ananyev, George Mason University, Fairfax,VA USA
Posted by administrator on Saturday, June 30 @ 06:31:31 EDT (515 reads) (Read More... | 14988 bytes more | Score: 0)

Mysterious Siberian Blasts Warned Point To Rapid Pole Reversal
Pole Reversal An unsettling report prepared by Viktor Seleznyov, director of the Geophysical Institute at the Siberian branch of the Russian Academy of Sciences (SB RAS), on the 6.8 magnitude earthquake that struck the Tyva Republic in Russia’s East Siberia earlier today warns that more seismic activity should be expected within the coming weeks and that this event is part of an ever increasing body of evidence pointing to a “rapid” shifting in our Earth’s magnetic poles.

Director Seleznyov, and other SB RAS scientists, have been increasingly concerned over the past fortnight about this region after the 9 February and 12 February “mysterious blasts” in the Kemerovo Region reminiscent of the 30 June 1908 Tunguska Event that remains the largest explosion of its type in modern times that for over a century has yet to be fully explained. The “common linkage” between these mysterious explosions and increasing seismic events in Siberia, this report says, is due to the rapid shifting of our Earth’s magnetic North Pole that has doubled in the last 50 years, and in the 1990s “picked up speed in a big way,” bolting north–northwest into the Arctic Ocean at more than 55 kilometers per year.
To the most immediate effect upon our Earth due to this “magnetic pole anomaly,” this report continues, has been the “strange disruption” of the jet stream over the Northern Hemisphere that on the North American side has produced the driest and warmest winter weather in recorded history, but on the European side has caused record-setting cold and snow that has claimed over 650 lives.
Though Director Seleznyov notes in this report that the evidence for a “full scale” geomagnetic reversal of the positions of magnetic north and magnetic south are still being debated, our Earth is, “without a doubt,” currently undergoing a Laschamp-type geomagnetic “event” known as a geomagnetic excursion.

A geomagnetic excursion, like a geomagnetic reversal, is a significant change in the Earth’s magnetic field. Unlike reversals however, an excursion does not permanently change the large-scale orientation of the field, but rather represents a dramatic, typically short-lived decrease in field intensity, with a variation in pole orientation of up to 45 degrees from the previous position.

Posted by administrator on Wednesday, February 29 @ 12:26:14 EST (395 reads) (Read More... | 6107 bytes more | Score: 0)

U.S. Healthcare Hits $3 Trillion
U.S. Healthcare Hits $3 Trillion Great post by Rick Ungar over on The Policy Page.  Still, I"m left wondering.  It"s an election year and given the stakes, I think well look back on 2012 as the year of the great Healthcare Reform debate – Part 2.  What we have today is really just the beginning of a long and winding investment in Healthcare Reform – Part 1.  I think the question remains  - have we tamed the cost beast with real legislation – or is it just legislation around the edges?  Here"s why I"m wondering.

1. National Healthcare Expenditure – or NHE. Total agreement with Rick that costs are “out-of-control” because our NHE is really $3 trillion – this year.  Actually, NHE for 2012 is probably closer to $2.7 trillion but there"s this nagging bookkeeping accrual of about $300 billion where we (narrowly) avoided those darn pesky SGR cuts to Medicare.  It"s come to be known affectionately as “doc fix” – and we"ve kicked that can down the road for 9 consecutive years.  Maybe we"ll just write it off – and maybe we should – but it"s actually on the books so we can"t just ignore it – can we?  That puts the real NHE at about $3 trillion for 2012 (+ about 4% for each year forward – as far as the eye can see).  As one economist said – we don"t have a debt problem in this country – we have a healthcare problem.

2. Accountable Care Organizations – or ACO"s. The current math is that ACO"s (a key aspect of Obama care) will accrue “just under $1 billion in savings” over the next three years.  Our NHE is $3 trillion – per year.  That $333 million per year savings is a fairly insignificant 0.01%.  Savings aside, the CBO just announced the results of a 20 year study that negates much of the entire ACO and “bundling payment” premise.  From a FierceHealthcare article referencing CBO"s own blog post yesterday - “After two decades of trying to shift toward rewarding quality care, disease management and care coordination demonstrations and value-based payment demonstrations have not reduced Medicare spending.  The report found that on average, the 34 disease management and care coordination programs designed to improve the quality of care for chronically ill Medicare patients barely affected hospital admissions.  For almost every program, spending stayed the same or, after considering the fees paid to participating organizations, it rose.
Posted by administrator on Thursday, January 26 @ 14:12:23 EST (503 reads) (Read More... | 11122 bytes more | Score: 0)

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